 |
| Scientific Info | | Study on safety and bioavailability of ubiquinol (Kaneka QH(trade mark)) after single and 4-week multiple oral administration to healthy volunteers. | The safety and bioavailability of ubiquinol (the reduced form of coenzyme Q(10 were evaluated for the first time in single-blind, placebo-controlled studies.
Kazunori Hosoe, Mitsuaki Kitano, Hideyuki Kishida, Hiroshi Kubo, Kenji Fujii, Mikio Kitahara
Pharmacology and Toxicology Group, Life Science Research Laboratories, Kaneka Corporation, 1-8 Miyamae-machi, Takasa-cho, Takasago-shi, Hyogo 676-8688, Japan |
| Reduced coenzyme Q10 supplementation decelerates senescence in SAMP1 mice. | Jingmin Yan, Kenji Fujii, Junjie Yao, Hideyuki Kishida, Kazunori Hosoe, Jinko Sawashita, Toshio Takeda, Masayuki Mori, Keiichi Higuchi
Department of Aging Biology, Institute on Aging and Adaptation, Shinshu University Graduate School of Medicine, 3-1-1, Asahi, Matsumoto 390-8621, Japan |
| Cancer - Apparent partial remission of breast cancer in 'high risk' patients supplemented with nutritional antioxidants, essential fatty acids and coenzyme Q10. | Thirty-two typical patients with breast cancer, aged 32-81 years and classified 'high risk' because of tumor spread to the lymph nodes in the axilla, were studied for 18 months following an Adjuvant Nutritional Intervention in Cancer protocol (ANICA protocol)
Mol Aspects Med 1994; 15 Suppl: s231-40.
Lockwood K, Moesgaard S, Hanioka T, Folkers K. |
| Coenzyme Q10 in cancer chemotherapy - experimental studies on augmentation of the effects of masked compounds, especially in the combined chemotherapy with immunopotentiators | Findings suggest the usefulness of coenzyme Q10 for the enhancement of cancer immunochemotherapy using masked compounds combined with immunopotentiators
Gan To Kagaku Ryoho 1983 Mar; 10(3): 768-74.
Kokawa T, Shiota K, Oda K, Okubo S, Okamoto Y, Okubo H. |
| Coenzyme Q10 - Apparent partial remission of breast cancer in 'high risk' patients supplemented with nutritional antioxidants, essential fatty acids and coenzyme Q10. | Apparent partial remission of breast cancer in 'high risk' patients supplemented with coenzyme Q10
Mol Aspects Med 1994; 15 Suppl: s231-40.
Lockwood K, Moesgaard S, Hanioka T, Folkers K. |
| | | | | Supplier: Inno-Vite | | Brand: Inno-vite | | Case Size: 24 | | INNO-Q-NOL 50 mg
30 sgels | | | Stock #: 140971 | | Description: The next generation of CoQ10, Ubiquinol is the strongest lipid soluble antioxidant available.
- Ubiquinol is the active, antioxidant form of CoQ10
- Most circulating CoQ10 (95%) in the blood is in this activated form
- Both Ubiquinol and Ubiquinone are forms of CoQ10 that are necessary for the production of cellular energy and life sustaining qualities.
- Until now, most supplements available on the market contained the ubiquinone form of CoQ10
- Biochemically, ubiquinone must be converted by the body to the active ubiquinol form in order to start working effectively as a potent antioxidant and cellular nutrient
- Ubiquinol is the active antioxidant form of CoQ10 and body ready for cellular energy production – no need for conversion in the body.
- The conversion into the active antioxidant ubiquinol form is not optimal in all individuals especially those who are older (over 40 years of age), have age-related diseases (heart disease, diabetes, neurodegenerative disease) or are in highly oxidative states (athletes)
- Research indicates that those in the categories mentioned above have lower ubiquinol levels and can benefit dramatically with ubiquinol supplementation
- It is highly stabilized through a patented process from Kaneka Corporation, Japan – the world’s largest CoQ10 producer and the makers of the only yeast fermented CoQ10.
- Since ubiquinol is easily oxidized in the air, researchers at Kaneka spent ten years in pursuit of stabilized ubiquinol that would enhance the activity of CoQ10
- The result is stabilized Ubiquinol which remains in antioxidant form and is available via a supplement called INNO-Q-NOL which is distributed in Canada by INNO-VITE
- A review of published studies on human subjects reveals that it requires very high doses of conventional CoQ10 to achieve the same levels attainable with lower amounts of ubiquinol CoQ10.
Fast Facts
1. Ubiquinol is the active antioxidant form of CoQ10.
2. Normally, the conversion process from CoQ10 to Ubiquinol occurs naturally in the body. But the 40+ population and those suffering from oxidative stress have difficulty converting it; Inno-Q-Nol provides the “pre-converted” form of CoQ10.
3. A recent study on mice showed that while those who supplemented with CoQ10 saw significant benefits, their ability to reduce CoQ10 into Ubiquinol began to diminish by late middle age. Those who supplemented with stabilized ubiquinol showed marked improvement in both physical appearance and activity into old age.
| | Benefits & How it Works: CoQ10, a compound found in all cells, helps
create energy in the cell. Seen almost as the battery for the cell, adequate amounts of CoQ10 ensure efficient functioning of cellular
processes. Since CoQ10 provides energy to the cell, it is understandable that the highest concentrations of this vital nutrient are found in heart muscle. An organ which is constantly
working, the heart has a huge demand for CoQ10;
in turn, a deficiency can worsen problems such as angina, cardiomyopathy (heart muscle dysfunction) and high blood pressure.
One of the most remarkable studies on CoQ10 involved the significant improvement of individuals expected to die of heart failure. When these patients were given CoQ10, they
astounded physicians by improving blood pumping capabilities and reducing heart size, outliving researcher’s expectations. Since this study, many more clinical trials have been conducted to unveil CoQ10’s immense value in treating heart patients. CoQ10 has also been shown to be quite
effective in reducing mild to moderate hypertension (blood pressure), as well as counteracting the serious adverse effects of cholesterol-lowering medications called statins.
After 10 years of painstaking research, Kaneka Corp., the worlds largest producer of CoQ10, have stabilized Ubiquinol: Kaneka QHTM which is marketed and distributed by Inno-Vite under the brand name- Inno-Q-nol.
The Body Must Activate CoQ10
Until now, most CoQ10 supplements on the market offered the ubiquinone form of CoQ10. What the lay literature did not discuss was the fact that in order for this standard CoQ10 (ubiquinone) to be properly utilized, it first must be
converted in the body to its active metabolite known as Ubiquinol. While most ubiquinone is naturally activated to ubiquinol, the optimal
way to supplement with CoQ10 would be to ingest it in its ready-to-use ubiquinol form. As you age, not only do you produce less CoQ10, but your
body becomes less efficient at converting CoQ10 to the active form - ubiquinol.
Why Should I Be Concerned About Declining Ubiquinol Levels?
Since increasing age causes a lessening ability to activate standard CoQ10 (ubiquinone), even ongoing supplementation with ubiquinone may not provide the total benefits of this vital nutrient.
Decline in activated CoQ10 (ubiquinol) in the blood result in less cellular energy and diminished protection against oxidative stress, which produces free radicals and can damage
the body’s cells, including proteins, lipids and DNA. Ubiquinol provides a strong first-stage defense against this cellular oxidative damage and needs to be replenished to maintain optimum health.
Why Ubiquinol Is Superior to Standard CoQ10 (Ubiquinone)?
What seems to excite researchers is that only modest doses of ubiquinol can achieve the same, if not better, results than standard CoQ10 supplements. Considered a scientific breakthrough, only in the last few years has technology enabled people to gain access to stabilized ubiquinol CoQ10 for the first time.
Compared to standard CoQ10 supplements, ubiquinol
absorbed in the bloodstream up to eight times better , reduced exercise-induced fatigue 90% more , and slowed aging in middle-age mice 40% better . In experimental studies, ubiquinol was also shown to achieve 3.75 times higher plasma concentrations after eight hours than standard
CoQ10 (Ubiquinone). A review of published studies on human subjects reveals that it requires very high doses of conventional CoQ10 to achieve the same levels attainable with modest amounts of
Ubiquinol CoQ10.
Who Should Consider Taking Ubiquinol?
The process of activating standard CoQ10 requires a complex set of reactions to occur. Supplementing with ubiquinol rather than standard CoQ10 (ubiquinone) is especially important for individuals who may have difficulty with the natural conversion of CoQ10 to ubiquinol, such as:
• The late middle-aged to elderly
• Individuals suffering from specific conditions, especially related to oxidative stress including diabetics, those with liver disease and with heart disease
Anti-fatigue: Kaneka Corporation recently conducted a study to compare the anti-fatigue effects of the ubiquinol and ubiquinone forms of CoQ10. In this study, aged rats were selected to measure how long they could run on a treadmill.
The control group using no CoQ10 showed a slight decline in running times. The group receiving the ubiquinone form of CoQ10 had a 60% increase in running time while the group receiving ubiquinol had a 150% increase in running time.
Diabetes: Type 2 diabetics suffer from elevated oxidative stress resulting in autonomic nervous system dysfunction. Japanese researchers found that as the day proceeded, so did levels of oxidative stress. This oxidative stress depletes
ubiquinol levels faster than ubiquinone. In fact, diabetics had approximately 75% less ubiquinol than the non-diabetic control group. This in turn means that individuals with diabetes must supplement with ubiquinol, as the process of activation is not optimal in even early stages of the disease.
Liver disease: Researchers at the University of Tokyo found that, like Type 2 diabetics, people with certain types of liver disease including cirrhosis, hepatitis, and hepatoma, suffered
from elevated oxidative stress which contributed to a decrease in ubiquinol levels.
Anti-aging: Although many factors can reduce CoQ10
levels in the blood, the aging process seems to elicit a 72% reduction in CoQ10 concentrations in the heart muscle wall. Researchers studying the anti-aging effects of CoQ10 found that ubiquinol was 40% more effective than standard ubiquinone in slowing markers of aging in middle-aged
mice. Markers such as joint and spine degeneration, as well as fatigue, were much less in the group given ubiquinol.
How much Inno-Q-Nol (Ubiqionol)should I take?
The recommended dose of Inno-Q-Nol varies based on
each individual’s needs and specific condition being treated. However, those who are older, suspect they have decreased CoQ10 due to disease, or are taking statin drugs may want to start supplementing with 200-300 mg of Inno-Q-Nol per day. Then, 100-200 mg per day is a good maintenance dose. | | Dosages & Ingredients: Each softgel contains:
Ubiquinol(Kaneka QH - active form of Q10)....50mg
Non medicinal ingredients:
medium chain triglycerides, gelatin, glycerin, ascorbyl palmitate, purified water, beeswax, soy lecithin and annatto extract
Recommended Adult Dosage:
Adults take 1 softgel daily or as directed by your health care practitioner.
| | | Cautions: If you are taking blood thinners consult with a health care practitiioner. | | |
|
|
